2920938-90-3
Most orderedN-Acetyl Semax Amidate
Terminally protected Semax analogue — N-acetylated, C-amidated. Released at ≥ 99.0% by RP-HPLC.
Typical release99.5%
From
£39.00
In stock
Neurological & Cognitive
Semax
MEHFPGP · ACTH(4-7)-Pro-Gly-Pro
The unmodified Semax heptapeptide with free termini. Reference compound for the analogue series.
Total, ex VAT
£32.00
- Released at ≥ 99.0% (RP-HPLC, area %)
- Identity confirmed by ESI-MS against theoretical mass
- Batch certificate matched to the vial, verifiable online
- Same working day dispatch before 14:00, tracked
For laboratory research use only. Not for human or veterinary use, and not a medicine, food or cosmetic. Sold to qualified researchers and institutions who accept responsibility for safe handling and lawful use.
Compound data
What is in the vial
Indicative values for this line. The certificate issued with your batch is the authoritative record and reports the measured figures for the material you receive.
- CAS number
- 80714-61-0
- Molecular formula
- C37H51N9O10S
- Average mass
- 813.94 g/mol
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro
- Residues
- 7
- Class
- ACTH(4-7) analogue with Pro-Gly-Pro extension
- Form as supplied
- Lyophilised powder
- Appearance
- White to off-white lyophilised powder
- Purity specification
- ≥ 99.0% (RP-HPLC, area %)
- Solubility
- Soluble in sterile or bacteriostatic water.
- Storage
- Lyophilised: −20 °C, desiccated and dark. Reconstituted: 2–8 °C.
Targets and pathways
- BDNF and NGF expression
- Monoamine turnover
- Melanocortin-independent — no corticotropic activity
Overview
About Semax
Semax is the parent compound of the series: the ACTH(4-7) tetrapeptide MEHF extended at the C-terminus with Pro-Gly-Pro. That extension is a protease block — proline-rich C-termini resist carboxypeptidase cleavage — and it is what made a fragment with a half-life of seconds usable at all.
It is stocked alongside the terminally capped analogue because comparing the two is how the effect of terminal protection is measured. Where a protocol specifies Semax, the unmodified peptide is what it means; substituting the capped analogue changes mass, retention time and solubility and will not reproduce the original method.
In short
- Unmodified heptapeptide with free N and C termini
- Pro-Gly-Pro C-terminal extension blocks carboxypeptidase cleavage
- Reference compound against which the capped analogue is compared
- Released at ≥ 99.0% area-percent by RP-HPLC
Where it is used
Research applications
Neurotrophin expression
The core reported effect of the series: upregulation of BDNF and NGF transcripts and protein in neuronal preparations.
Analogue comparison
Held alongside N-Acetyl Semax Amidate to isolate the effect of terminal capping on half-life and distribution.
Ischaemia models
An extensive body of work in cerebral ischaemia models, largely published in Russian-language journals.
Handling
Reconstitution and stability
Reconstitution
Reconstitute with sterile or bacteriostatic water added slowly against the inner wall of the vial. Allow the cake to dissolve without agitation, swirling gently if required. Do not vortex or shake.
Stability
Lyophilised at −20 °C, desiccated and protected from light, stable for at least 24 months. Reconstituted and held at 2–8 °C, use within 28 days. Avoid repeated freeze-thaw.
Notes
- Bring the vial to room temperature before opening so atmospheric moisture does not condense onto cold powder.
- Record the reconstitution date on the vial; concentration drift between runs is usually evaporation, not synthesis variance.
- Aliquot at first reconstitution where the working programme needs more than a few withdrawals.
Laboratory reference
Reconstitution calculator
Enter the fill weight on the vial and the diluent volume you intend to add. The calculator returns the resulting solution concentration and the volume that contains a given mass.
- Concentration
- 5.000 mg/mL · 5000 µg/mL
- Volume containing target mass
- 50.0 µL · 0.0500 mL
Figures are mass-to-volume arithmetic for laboratory preparation of Semax and take no account of net peptide content, which is stated on the batch certificate and should be applied to the fill weight before calculating. Nothing here constitutes dosing, administration or clinical guidance of any kind.
Published work
What the literature reports
Summaries of published findings, provided as research reference. These describe work done by others in preclinical and clinical settings; they are not claims about this material or outcomes for any reader.
Neurotrophin induction
Increased BDNF protein and transcript reported in rat hippocampal preparations following exposure.
Dolotov et al., Journal of Neuroscience Research, 2006
Fragment structure–activity
Work separating the neurotrophic activity of short ACTH fragments from adrenal stimulation.
Ashmarin et al., Neuroscience and Behavioral Physiology
Questions
Semax — asked and answered
Something not covered here? Ask us directly — technical questions reach someone who runs the assays.
- Should I use this or the amidate?
- Use whichever your protocol specifies. They are different compounds. If you are designing new work, the capped analogue has the longer solution half-life; if you are reproducing published work, match what the original used.
- Does it have corticotropic activity?
- No. The ACTH(4-7) fragment lacks the residues needed for melanocortin-2 receptor activation.
- Is it oxidation-sensitive?
- Yes, mildly. The single methionine oxidises on air exposure in solution. Expect a small early-eluting peak in an ageing preparation.
Same class
Others in Neurological & Cognitive
Important
Semax is supplied strictly for laboratory research and analytical use. It is not a medicine, food, cosmetic or veterinary product; it is not for human or animal consumption; and it is not intended to diagnose, treat, cure or prevent any condition. It is not manufactured, tested or released to any standard that would support administration to humans or animals. Information on this page is compiled for research reference and is not medical advice. No dosing, administration or therapeutic guidance is given or implied. By ordering you confirm you are a qualified researcher or institution and accept responsibility for safe handling and lawful use.