9 guides
How the analysis works, what a certificate does and does not tell you, and how to keep material within specification once it is in your freezer. No marketing, no dosing, no claims about outcomes.
5 guides
14 May 2026 · 9 min
Chromatography tells you a sample is homogeneous. Mass spectrometry tells you what it is. The distinction is the difference between a clean chromatogram and a confirmed identity.
30 Apr 2026 · 10 min
Reversed-phase HPLC is the default method for peptide purity, and the figure it produces depends on choices made before the sample is injected. Here is what those choices are.
16 Apr 2026 · 11 min
Purity is not one number. It is a set of separate measurements answering separate questions, and a certificate reporting only one of them is telling you less than it appears to.
19 Mar 2026 · 8 min
A certificate of analysis is a record of what was measured on a specific batch, by whom, and when. Understanding what it is — and what it is not — is the first step in using one properly.
26 Feb 2026 · 10 min
An annotated walk through a real certificate: what each field means, what a good value looks like, and which line most people use incorrectly.
2 guides
05 Mar 2026 · 9 min
Freeze-drying is not simply removing water. It changes the physical state of the material, and most reconstitution problems trace back to what happened during the drying.
12 Feb 2026 · 10 min
Four variables determine how long material holds specification. Getting them right is inexpensive; getting them wrong quietly invalidates results months before anyone notices.
2 guides
11 Jun 2026 · 9 min
A mitochondrial peptide that regulates a nuclear metabolic sensor. What the primary literature establishes, what it does not, and what that means for anyone designing work with it.
28 May 2026 · 8 min
N-acetylation and C-amidation are protective modifications, not pharmacophoric ones. Understanding that distinction is what keeps a Semax protocol reproducible when the analogue changes.
How these are written
Compound guides are written from the primary literature, cited by author and journal so you can go and read it. Where a body of evidence is thin, contested, or drawn from a small number of groups, these guides say so — and where a finding is a mouse finding, it is described as a mouse finding. That is less exciting than the summaries circulating elsewhere and considerably more useful when you are designing an experiment.