2920938-90-3
Most orderedN-Acetyl Semax Amidate
Terminally protected Semax analogue — N-acetylated, C-amidated. Released at ≥ 99.0% by RP-HPLC.
Typical release99.5%
From
£39.00
In stock
Neurological & Cognitive
Selank
TP-7 · Thr-Lys-Pro-Arg-Pro-Gly-Pro
Tuftsin analogue with a Pro-Gly-Pro extension, studied in anxiolytic and immunomodulatory models.
Total, ex VAT
£38.00
- Released at ≥ 98.0% (RP-HPLC, area %)
- Identity confirmed by ESI-MS against theoretical mass
- Batch certificate matched to the vial, verifiable online
- Same working day dispatch before 14:00, tracked
For laboratory research use only. Not for human or veterinary use, and not a medicine, food or cosmetic. Sold to qualified researchers and institutions who accept responsibility for safe handling and lawful use.
Compound data
What is in the vial
Indicative values for this line. The certificate issued with your batch is the authoritative record and reports the measured figures for the material you receive.
- CAS number
- 129954-34-3
- Molecular formula
- C33H57N11O9
- Average mass
- 751.88 g/mol
- Sequence
- Thr-Lys-Pro-Arg-Pro-Gly-Pro
- Residues
- 7
- Class
- Tuftsin analogue heptapeptide
- Form as supplied
- Lyophilised powder
- Appearance
- White to off-white lyophilised powder
- Purity specification
- ≥ 98.0% (RP-HPLC, area %)
- Solubility
- Soluble in sterile or bacteriostatic water.
- Storage
- Lyophilised: −20 °C, desiccated and dark. Reconstituted: 2–8 °C.
Targets and pathways
- GABAergic signalling
- Enkephalin degradation pathways
- Tuftsin-associated immune signalling
Overview
About Selank
Selank is built on tuftsin, the endogenous immunomodulatory tetrapeptide TKPR, extended with the same Pro-Gly-Pro protease block used in Semax. The two compounds come from the same design programme and share that stabilising strategy, which is why they are often studied together.
Research interest spans two areas that are usually separate: anxiolytic effects mediated through GABAergic signalling and inhibition of enkephalin degradation, and immunomodulatory effects inherited from the tuftsin backbone. That the same short sequence appears in both literatures is part of what makes it interesting as a tool compound.
In short
- Tuftsin (TKPR) extended with a Pro-Gly-Pro protease block
- Same stabilisation strategy as Semax, from the same design programme
- Studied across both anxiolytic and immunomodulatory endpoints
- Released at ≥ 98.0% area-percent by RP-HPLC
Where it is used
Research applications
GABAergic signalling
Reported effects on GABA receptor expression underpin most of the anxiolytic work with the compound.
Enkephalin metabolism
Inhibition of enkephalin-degrading enzymes is a proposed mechanism, connecting the peptide to endogenous opioid signalling.
Immunomodulation
Effects inherited from the tuftsin backbone, including on phagocyte function and cytokine expression.
Handling
Reconstitution and stability
Reconstitution
Reconstitute with sterile or bacteriostatic water added slowly against the inner wall of the vial. Allow the cake to dissolve without agitation, swirling gently if required. Do not vortex or shake.
Stability
Lyophilised at −20 °C, desiccated and protected from light, stable for at least 24 months. Reconstituted and held at 2–8 °C, use within 28 days. Avoid repeated freeze-thaw.
Notes
- Bring the vial to room temperature before opening so atmospheric moisture does not condense onto cold powder.
- Record the reconstitution date on the vial; concentration drift between runs is usually evaporation, not synthesis variance.
- Aliquot at first reconstitution where the working programme needs more than a few withdrawals.
Laboratory reference
Reconstitution calculator
Enter the fill weight on the vial and the diluent volume you intend to add. The calculator returns the resulting solution concentration and the volume that contains a given mass.
- Concentration
- 5.000 mg/mL · 5000 µg/mL
- Volume containing target mass
- 50.0 µL · 0.0500 mL
Figures are mass-to-volume arithmetic for laboratory preparation of Selank and take no account of net peptide content, which is stated on the batch certificate and should be applied to the fill weight before calculating. Nothing here constitutes dosing, administration or clinical guidance of any kind.
Published work
What the literature reports
Summaries of published findings, provided as research reference. These describe work done by others in preclinical and clinical settings; they are not claims about this material or outcomes for any reader.
Anxiolytic characterisation
Behavioural work establishing anxiolytic effects and proposing a GABAergic mechanism.
Kozlovskii & Danchev, Neuroscience and Behavioral Physiology
Gene expression response
Transcriptome analysis reporting changes in immune and neurotransmitter-related gene sets following exposure.
Volkova et al., Frontiers in Pharmacology, 2016
Questions
Selank — asked and answered
Something not covered here? Ask us directly — technical questions reach someone who runs the assays.
- How does it relate to Semax?
- Both use the same Pro-Gly-Pro C-terminal protease block, but the active sequences differ — Semax from ACTH(4-7), Selank from tuftsin. They are distinct compounds studied for different endpoints.
- Is it stable in solution?
- Yes, 28 days at 2–8 °C. It contains no methionine or cysteine, so it is less oxidation-sensitive than Semax.
- What purity is it released at?
- ≥ 98.0% area-percent by RP-HPLC with identity by ESI-MS. Typical released purity is around 99.1%.
Same class
Others in Neurological & Cognitive
Important
Selank is supplied strictly for laboratory research and analytical use. It is not a medicine, food, cosmetic or veterinary product; it is not for human or animal consumption; and it is not intended to diagnose, treat, cure or prevent any condition. It is not manufactured, tested or released to any standard that would support administration to humans or animals. Information on this page is compiled for research reference and is not medical advice. No dosing, administration or therapeutic guidance is given or implied. By ordering you confirm you are a qualified researcher or institution and accept responsibility for safe handling and lawful use.