2920938-90-3
Most orderedN-Acetyl Semax Amidate
Terminally protected Semax analogue — N-acetylated, C-amidated. Released at ≥ 99.0% by RP-HPLC.
Typical release99.5%
From
£39.00
In stock
Neurological & Cognitive
Dihexa
N-hexanoic-Tyr-Ile-(6) aminohexanoic amide · PNB-0408
Angiotensin IV analogue studied as an HGF/c-Met potentiator in synaptogenesis models.
Total, ex VAT
£89.00
- Released at ≥ 98.0% (RP-HPLC, area %)
- Identity confirmed by ESI-MS against theoretical mass
- Batch certificate matched to the vial, verifiable online
- Same working day dispatch before 14:00, tracked
For laboratory research use only. Not for human or veterinary use, and not a medicine, food or cosmetic. Sold to qualified researchers and institutions who accept responsibility for safe handling and lawful use.
Compound data
What is in the vial
Indicative values for this line. The certificate issued with your batch is the authoritative record and reports the measured figures for the material you receive.
- CAS number
- 1401708-83-5
- Molecular formula
- C24H36N4O5
- Average mass
- 460.57 g/mol
- Class
- Angiotensin IV analogue
- Form as supplied
- Lyophilised powder
- Appearance
- White to off-white lyophilised powder
- Purity specification
- ≥ 98.0% (RP-HPLC, area %)
- Solubility
- Poorly soluble in water. DMSO stock followed by aqueous dilution is standard.
- Storage
- Lyophilised: −20 °C, desiccated and dark. Reconstituted: 2–8 °C.
Targets and pathways
- Hepatocyte growth factor / c-Met receptor system
Overview
About Dihexa
Dihexa is a small angiotensin IV-derived molecule developed to potentiate hepatocyte growth factor signalling at the c-Met receptor. It is not a conventional peptide — the hexanoic acid and aminohexanoic amide groups make it substantially more lipophilic than the parent sequence, which was the design goal.
Research use centres on synaptogenesis. Potentiating HGF/c-Met signalling is studied for effects on dendritic spine formation and synaptic connectivity, which is why the compound appears in cognitive and neurorepair models rather than in the cardiovascular literature where angiotensin IV analogues would otherwise sit.
In short
- Angiotensin IV-derived, heavily modified for lipophilicity
- Studied as an HGF/c-Met potentiator rather than a direct agonist
- Poorly water-soluble — DMSO stock required
- Released at ≥ 98.0% area-percent by HPLC
Where it is used
Research applications
Synaptogenesis
Dendritic spine formation and synaptic density are the principal measured endpoints in work with this compound.
HGF/c-Met signalling
Used as a pharmacological tool to potentiate an endogenous growth factor system rather than to substitute for it.
Angiotensin IV pharmacology
Part of the broader effort to separate the cognitive effects of the AT4 system from its cardiovascular ones.
Handling
Reconstitution and stability
Reconstitution
Reconstitute with sterile or bacteriostatic water added slowly against the inner wall of the vial. Allow the cake to dissolve without agitation, swirling gently if required. Do not vortex or shake.
Stability
Lyophilised at −20 °C, desiccated and protected from light, stable for at least 24 months. Reconstituted and held at 2–8 °C, use within 28 days. Avoid repeated freeze-thaw.
Notes
- Bring the vial to room temperature before opening so atmospheric moisture does not condense onto cold powder.
- Record the reconstitution date on the vial; concentration drift between runs is usually evaporation, not synthesis variance.
- Aliquot at first reconstitution where the working programme needs more than a few withdrawals.
Laboratory reference
Reconstitution calculator
Enter the fill weight on the vial and the diluent volume you intend to add. The calculator returns the resulting solution concentration and the volume that contains a given mass.
- Concentration
- 2.500 mg/mL · 2500 µg/mL
- Volume containing target mass
- 100.0 µL · 0.1000 mL
Figures are mass-to-volume arithmetic for laboratory preparation of Dihexa and take no account of net peptide content, which is stated on the batch certificate and should be applied to the fill weight before calculating. Nothing here constitutes dosing, administration or clinical guidance of any kind.
Published work
What the literature reports
Summaries of published findings, provided as research reference. These describe work done by others in preclinical and clinical settings; they are not claims about this material or outcomes for any reader.
Design and synaptogenic activity
Description of the compound's development from angiotensin IV and demonstration of synaptogenic activity in hippocampal cultures.
McCoy et al., Journal of Pharmacology and Experimental Therapeutics, 2013
HGF/c-Met dependence
Work establishing that the synaptogenic effect requires an intact HGF/c-Met system.
Benoist et al., Journal of Pharmacology and Experimental Therapeutics, 2014
Questions
Dihexa — asked and answered
Something not covered here? Ask us directly — technical questions reach someone who runs the assays.
- How should it be dissolved?
- Prepare a DMSO stock and dilute into aqueous buffer immediately before use. Direct aqueous preparation typically fails to give a true solution.
- Is it a peptide?
- It is peptide-derived but heavily modified, with non-amino-acid groups at both ends. For handling and assay purposes treat it as a small molecule.
- What DMSO concentration is tolerable?
- That depends on your cell system. Confirm vehicle tolerance separately — we cannot advise on assay design.
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Important
Dihexa is supplied strictly for laboratory research and analytical use. It is not a medicine, food, cosmetic or veterinary product; it is not for human or animal consumption; and it is not intended to diagnose, treat, cure or prevent any condition. It is not manufactured, tested or released to any standard that would support administration to humans or animals. Information on this page is compiled for research reference and is not medical advice. No dosing, administration or therapeutic guidance is given or implied. By ordering you confirm you are a qualified researcher or institution and accept responsibility for safe handling and lawful use.