1627580-64-6
Most orderedMOTS-c
A 16-residue mitochondrial-derived peptide encoded in mtDNA. Supplied lyophilised, released at ≥ 99.0% by RP-HPLC.
Typical release99.2%
From
£86.00
In stock
Mitochondrial & Longevity
SS-31
Elamipretide · MTP-131 · Bendavia
Cardiolipin-binding tetrapeptide that concentrates in the inner mitochondrial membrane.
Total, ex VAT
£118.00
- Released at ≥ 99.0% (RP-HPLC, area %)
- Identity confirmed by ESI-MS against theoretical mass
- Batch certificate matched to the vial, verifiable online
- Same working day dispatch before 14:00, tracked
For laboratory research use only. Not for human or veterinary use, and not a medicine, food or cosmetic. Sold to qualified researchers and institutions who accept responsibility for safe handling and lawful use.
Compound data
What is in the vial
Indicative values for this line. The certificate issued with your batch is the authoritative record and reports the measured figures for the material you receive.
- CAS number
- 736992-21-5
- Molecular formula
- C32H49N9O5
- Average mass
- 639.79 g/mol
- Sequence
- D-Arg-Dmt-Lys-Phe-NH2
- Residues
- 4
- Class
- Mitochondria-targeting tetrapeptide
- Form as supplied
- Lyophilised powder
- Appearance
- White to off-white lyophilised powder
- Purity specification
- ≥ 99.0% (RP-HPLC, area %)
- Solubility
- Soluble in sterile or bacteriostatic water.
- Storage
- Lyophilised: −20 °C, desiccated and dark. Reconstituted: 2–8 °C.
Targets and pathways
- Cardiolipin in the inner mitochondrial membrane
Overview
About SS-31
SS-31 is a four-residue aromatic-cationic peptide with an alternating charge motif that drives accumulation in the inner mitochondrial membrane independently of membrane potential — an unusual property, since most mitochondrial-targeting agents rely on the potential gradient and therefore fail in exactly the depolarised mitochondria they are meant to reach.
It binds cardiolipin, the signature phospholipid of the inner membrane, and is studied for its effect on cristae architecture and electron transport efficiency. The D-arginine and dimethyltyrosine residues make it resistant to proteolysis, so it behaves more robustly in preparation than its length would suggest.
In short
- Accumulates in the inner mitochondrial membrane independently of membrane potential
- Binds cardiolipin rather than a protein receptor
- Contains D-arginine and 2,6-dimethyltyrosine — protease resistant
- Released at ≥ 99.0% area-percent by RP-HPLC
Where it is used
Research applications
Cristae architecture
Cardiolipin binding is studied for its effect on inner membrane curvature and the organisation of respiratory supercomplexes.
Ischaemia–reperfusion
The compound appears widely in reperfusion injury models, where mitochondrial permeability transition is the endpoint of interest.
Mitochondrial myopathy models
Used in skeletal and cardiac muscle preparations where electron transport efficiency is the measured variable.
Handling
Reconstitution and stability
Reconstitution
Reconstitute with sterile or bacteriostatic water added slowly against the inner wall of the vial. Allow the cake to dissolve without agitation, swirling gently if required. Do not vortex or shake.
Stability
Lyophilised at −20 °C, desiccated and protected from light, stable for at least 24 months. Reconstituted and held at 2–8 °C, use within 28 days. Avoid repeated freeze-thaw.
Notes
- Bring the vial to room temperature before opening so atmospheric moisture does not condense onto cold powder.
- Record the reconstitution date on the vial; concentration drift between runs is usually evaporation, not synthesis variance.
- Aliquot at first reconstitution where the working programme needs more than a few withdrawals.
Laboratory reference
Reconstitution calculator
Enter the fill weight on the vial and the diluent volume you intend to add. The calculator returns the resulting solution concentration and the volume that contains a given mass.
- Concentration
- 5.000 mg/mL · 5000 µg/mL
- Volume containing target mass
- 50.0 µL · 0.0500 mL
Figures are mass-to-volume arithmetic for laboratory preparation of SS-31 and take no account of net peptide content, which is stated on the batch certificate and should be applied to the fill weight before calculating. Nothing here constitutes dosing, administration or clinical guidance of any kind.
Published work
What the literature reports
Summaries of published findings, provided as research reference. These describe work done by others in preclinical and clinical settings; they are not claims about this material or outcomes for any reader.
Membrane-potential-independent uptake
Characterisation of the aromatic-cationic motif and demonstration that uptake does not require an intact membrane potential.
Zhao et al., Journal of Biological Chemistry, 2004
Cardiolipin interaction
Work establishing cardiolipin as the binding partner and linking that interaction to cristae morphology and supercomplex assembly.
Birk et al., Journal of the American Society of Nephrology, 2013
Questions
SS-31 — asked and answered
Something not covered here? Ask us directly — technical questions reach someone who runs the assays.
- Why does membrane-potential independence matter?
- Damaged mitochondria are depolarised. Agents that rely on the potential gradient concentrate least in the organelles that most need study. SS-31 does not have that limitation, which is why it appears so often in injury models.
- Does it contain unnatural amino acids?
- Yes. D-arginine and 2,6-dimethyltyrosine. Both are confirmed by mass on every certificate, and both contribute to its protease resistance.
- Is elamipretide the same compound?
- Yes. Elamipretide is the assigned international nonproprietary name for SS-31.
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Important
SS-31 is supplied strictly for laboratory research and analytical use. It is not a medicine, food, cosmetic or veterinary product; it is not for human or animal consumption; and it is not intended to diagnose, treat, cure or prevent any condition. It is not manufactured, tested or released to any standard that would support administration to humans or animals. Information on this page is compiled for research reference and is not medical advice. No dosing, administration or therapeutic guidance is given or implied. By ordering you confirm you are a qualified researcher or institution and accept responsibility for safe handling and lawful use.