1627580-64-6
Most orderedMOTS-c
A 16-residue mitochondrial-derived peptide encoded in mtDNA. Supplied lyophilised, released at ≥ 99.0% by RP-HPLC.
Typical release99.2%
From
£86.00
In stock
Mitochondrial & Longevity
Epitalon
Epithalon · Epithalamin tetrapeptide · AEDG
Synthetic tetrapeptide studied in telomerase expression and pineal regulation models.
Total, ex VAT
£36.00
- Released at ≥ 98.0% (RP-HPLC, area %)
- Identity confirmed by ESI-MS against theoretical mass
- Batch certificate matched to the vial, verifiable online
- Same working day dispatch before 14:00, tracked
For laboratory research use only. Not for human or veterinary use, and not a medicine, food or cosmetic. Sold to qualified researchers and institutions who accept responsibility for safe handling and lawful use.
Compound data
What is in the vial
Indicative values for this line. The certificate issued with your batch is the authoritative record and reports the measured figures for the material you receive.
- CAS number
- 307297-39-8
- Molecular formula
- C14H22N4O9
- Average mass
- 390.35 g/mol
- Sequence
- Ala-Glu-Asp-Gly
- Residues
- 4
- Class
- Synthetic regulatory tetrapeptide
- Form as supplied
- Lyophilised powder
- Appearance
- White to off-white lyophilised powder
- Purity specification
- ≥ 98.0% (RP-HPLC, area %)
- Solubility
- Soluble in sterile or bacteriostatic water.
- Storage
- Lyophilised: −20 °C, desiccated and dark. Reconstituted: 2–8 °C.
Targets and pathways
- Telomerase (TERT) expression
- Pineal regulatory pathways
Overview
About Epitalon
Epitalon is a four-residue peptide, Ala-Glu-Asp-Gly, developed as a synthetic counterpart to the pineal extract epithalamin. It is one of the shortest sequences in regular research use, and its small size and high polarity make it straightforward to handle but unusual to assay — it elutes very early on standard reversed-phase gradients and often needs a modified method.
The research interest centres on reported effects on telomerase expression in somatic cell cultures and on circadian and pineal regulation. Much of the primary literature is Russian-language and older, and secondary sources frequently overstate it, so the compound is best approached with the original methodology in hand.
In short
- Four residues, Ala-Glu-Asp-Gly — highly polar and early-eluting
- Standard reversed-phase gradients often need modification to retain it
- Studied in telomerase expression and pineal regulation models
- Released at ≥ 98.0% area-percent by RP-HPLC
Where it is used
Research applications
Telomerase expression
Reported induction of TERT expression in somatic cell culture is the most-cited line of work on the compound.
Circadian and pineal regulation
Derived from pineal extract research, the peptide appears in work on melatonin rhythm and pineal function.
Short-peptide bioregulation
The compound is a standard example in the broader literature on very short regulatory peptides and their proposed mechanism of action.
Handling
Reconstitution and stability
Reconstitution
Reconstitute with sterile or bacteriostatic water added slowly against the inner wall of the vial. Allow the cake to dissolve without agitation, swirling gently if required. Do not vortex or shake.
Stability
Lyophilised at −20 °C, desiccated and protected from light, stable for at least 24 months. Reconstituted and held at 2–8 °C, use within 28 days. Avoid repeated freeze-thaw.
Notes
- Bring the vial to room temperature before opening so atmospheric moisture does not condense onto cold powder.
- Record the reconstitution date on the vial; concentration drift between runs is usually evaporation, not synthesis variance.
- Aliquot at first reconstitution where the working programme needs more than a few withdrawals.
Laboratory reference
Reconstitution calculator
Enter the fill weight on the vial and the diluent volume you intend to add. The calculator returns the resulting solution concentration and the volume that contains a given mass.
- Concentration
- 5.000 mg/mL · 5000 µg/mL
- Volume containing target mass
- 50.0 µL · 0.0500 mL
Figures are mass-to-volume arithmetic for laboratory preparation of Epitalon and take no account of net peptide content, which is stated on the batch certificate and should be applied to the fill weight before calculating. Nothing here constitutes dosing, administration or clinical guidance of any kind.
Published work
What the literature reports
Summaries of published findings, provided as research reference. These describe work done by others in preclinical and clinical settings; they are not claims about this material or outcomes for any reader.
Telomerase induction in culture
Reported induction of telomerase activity and extension of replicative capacity in human somatic cell cultures.
Khavinson et al., Bulletin of Experimental Biology and Medicine, 2003
Peptide bioregulation
A review setting out the short-peptide bioregulator hypothesis and the place of AEDG within it.
Khavinson & Malinin, reviewed in Biogerontology
Questions
Epitalon — asked and answered
Something not covered here? Ask us directly — technical questions reach someone who runs the assays.
- Why does it elute so early on HPLC?
- It is four residues, highly polar and carries two acidic side chains. On a standard C18 gradient it can co-elute with the void. We use a modified method with a shallow initial gradient; if you are re-assaying, expect to adjust yours.
- Is Epitalon the same as Epithalon?
- Yes. Both spellings refer to the same AEDG tetrapeptide. Epithalamin is the pineal extract from which it was derived, and is a different, undefined preparation.
- How strong is the evidence base?
- Much of the primary literature is older and Russian-language, and secondary sources routinely overstate it. We supply the material to specification and leave the interpretation of the literature to the researcher.
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Important
Epitalon is supplied strictly for laboratory research and analytical use. It is not a medicine, food, cosmetic or veterinary product; it is not for human or animal consumption; and it is not intended to diagnose, treat, cure or prevent any condition. It is not manufactured, tested or released to any standard that would support administration to humans or animals. Information on this page is compiled for research reference and is not medical advice. No dosing, administration or therapeutic guidance is given or implied. By ordering you confirm you are a qualified researcher or institution and accept responsibility for safe handling and lawful use.