2381089-83-2
Most orderedRetatrutide
Single-molecule agonist at the GIP, GLP-1 and glucagon receptors. Supplied lyophilised and released at ≥ 99.0% by RP-HPLC.
Typical release99.4%
From
£68.00
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Metabolic & IncretinMost ordered
Semaglutide
NN9535
Acylated GLP-1 receptor agonist with a C18 diacid linker. The reference mono-agonist for incretin work.
Total, ex VAT
£44.00
- Released at ≥ 99.0% (RP-HPLC, area %)
- Identity confirmed by ESI-MS against theoretical mass
- Batch certificate matched to the vial, verifiable online
- Same working day dispatch before 14:00, tracked
For laboratory research use only. Not for human or veterinary use, and not a medicine, food or cosmetic. Sold to qualified researchers and institutions who accept responsibility for safe handling and lawful use.
Compound data
What is in the vial
Indicative values for this line. The certificate issued with your batch is the authoritative record and reports the measured figures for the material you receive.
- CAS number
- 910463-68-2
- Molecular formula
- C187H291N45O59
- Average mass
- 4113.58 g/mol
- Residues
- 31
- Class
- GLP-1 receptor agonist, acylated
- Form as supplied
- Lyophilised powder
- Appearance
- White to off-white lyophilised powder
- Purity specification
- ≥ 99.0% (RP-HPLC, area %)
- Solubility
- Soluble in sterile or bacteriostatic water.
- Storage
- Lyophilised: −20 °C, desiccated and dark. Reconstituted: 2–8 °C.
Targets and pathways
- Glucagon-like peptide-1 receptor (GLP-1R)
Overview
About Semaglutide
Semaglutide is a GLP-1 analogue built on the native backbone with two substitutions that solve its two failure modes: Aib at position 8 blocks DPP-4 cleavage, and a C18 diacid attached through a short spacer at position 26 confers strong albumin binding. Together they take a peptide with a half-life of minutes to one with a half-life of around a week.
In research use it is the standard mono-agonist comparator. Any claim about what a dual or tri-agonist adds is measured against a GLP-1-only reference, and semaglutide is almost always that reference — which makes purity of the comparator as consequential as purity of the test article.
In short
- Aib8 substitution confers DPP-4 resistance
- C18 diacid conjugation drives albumin binding and extended residence
- The standard GLP-1 mono-agonist comparator in multi-agonist studies
- Released at ≥ 99.0% area-percent by RP-HPLC
Where it is used
Research applications
Comparator studies
Used as the GLP-1-only reference arm when characterising what dual and tri-agonists add beyond GLP-1 receptor engagement.
Receptor pharmacology
Applied in cAMP accumulation and β-arrestin recruitment assays to characterise biased signalling at GLP-1R.
Gastric emptying models
GLP-1R agonism slows gastric emptying, a distinct effect from central appetite signalling and studied separately.
Handling
Reconstitution and stability
Reconstitution
Reconstitute with sterile or bacteriostatic water added slowly against the inner wall of the vial. Allow the cake to dissolve without agitation, swirling gently if required. Do not vortex or shake.
Stability
Lyophilised at −20 °C, desiccated and protected from light, stable for at least 24 months. Reconstituted and held at 2–8 °C, use within 28 days. Avoid repeated freeze-thaw.
Notes
- Bring the vial to room temperature before opening so atmospheric moisture does not condense onto cold powder.
- Record the reconstitution date on the vial; concentration drift between runs is usually evaporation, not synthesis variance.
- Aliquot at first reconstitution where the working programme needs more than a few withdrawals.
Laboratory reference
Reconstitution calculator
Enter the fill weight on the vial and the diluent volume you intend to add. The calculator returns the resulting solution concentration and the volume that contains a given mass.
- Concentration
- 1.000 mg/mL · 1000 µg/mL
- Volume containing target mass
- 250.0 µL · 0.2500 mL
Figures are mass-to-volume arithmetic for laboratory preparation of Semaglutide and take no account of net peptide content, which is stated on the batch certificate and should be applied to the fill weight before calculating. Nothing here constitutes dosing, administration or clinical guidance of any kind.
Published work
What the literature reports
Summaries of published findings, provided as research reference. These describe work done by others in preclinical and clinical settings; they are not claims about this material or outcomes for any reader.
Molecular design
The paper describing the structural basis for semaglutide's extended half-life, covering the Aib8 substitution and the diacid linker strategy.
Lau et al., Journal of Medicinal Chemistry, 2015
Cardiovascular outcomes
A large outcomes trial reporting reduced cardiovascular events, which established the class as more than a glycaemic agent.
Marso et al., New England Journal of Medicine, 2016
Questions
Semaglutide — asked and answered
Something not covered here? Ask us directly — technical questions reach someone who runs the assays.
- Which salt form is supplied?
- Acetate. The certificate reports residual acetate content, which matters where net peptide content is being calculated from gross vial weight.
- Is this the same as the branded product?
- No. This is research-grade material supplied for laboratory use. It is not manufactured or released to pharmaceutical standards and is not a medicine.
- How does purity affect comparator work?
- A comparator with related-substance peaks carrying residual receptor activity shifts the baseline you are measuring against. That is why we release the comparator lines at the same specification as the test articles.
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Important
Semaglutide is supplied strictly for laboratory research and analytical use. It is not a medicine, food, cosmetic or veterinary product; it is not for human or animal consumption; and it is not intended to diagnose, treat, cure or prevent any condition. It is not manufactured, tested or released to any standard that would support administration to humans or animals. Information on this page is compiled for research reference and is not medical advice. No dosing, administration or therapeutic guidance is given or implied. By ordering you confirm you are a qualified researcher or institution and accept responsibility for safe handling and lawful use.