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Metabolic & Incretin
5-Amino-1MQ
5-amino-1-methylquinolinium · 5A1MQ
Small-molecule NNMT inhibitor used in methylation and adipocyte metabolism research.
Total, ex VAT
£56.00
- Released at ≥ 98.0% (HPLC, area %)
- Identity confirmed by ESI-MS against theoretical mass
- Batch certificate matched to the vial, verifiable online
- Same working day dispatch before 14:00, tracked
For laboratory research use only. Not for human or veterinary use, and not a medicine, food or cosmetic. Sold to qualified researchers and institutions who accept responsibility for safe handling and lawful use.
Compound data
What is in the vial
Indicative values for this line. The certificate issued with your batch is the authoritative record and reports the measured figures for the material you receive.
- CAS number
- Stated on certificate
- Molecular formula
- C10H11N2+ (as iodide salt)
- Average mass
- 159.21 g/mol (cation)
- Class
- Nicotinamide N-methyltransferase (NNMT) inhibitor
- Form as supplied
- Lyophilised powder
- Appearance
- White to off-white lyophilised powder
- Purity specification
- ≥ 98.0% (HPLC, area %)
- Solubility
- Soluble in water and DMSO. Supplied as the iodide salt.
- Storage
- Lyophilised: −20 °C, desiccated and dark. Reconstituted: 2–8 °C.
Targets and pathways
- Nicotinamide N-methyltransferase (NNMT)
Overview
About 5-Amino-1MQ
5-Amino-1MQ is a small-molecule quaternary quinolinium that inhibits nicotinamide N-methyltransferase. It is not a peptide, and it is listed in the metabolic group because NNMT sits at the junction of methylation capacity and NAD+ salvage — the enzyme consumes both nicotinamide and the methyl donor SAM.
That dual consumption is what makes the inhibitor useful. Blocking NNMT raises intracellular nicotinamide available for the NAD+ salvage pathway while sparing SAM, so the compound is used to probe both arms in the same preparation rather than manipulating each separately.
In short
- Cell-permeable NNMT inhibitor, supplied as the iodide salt
- Not a peptide — assayed by a small-molecule HPLC method
- Links methylation capacity to NAD+ salvage in a single intervention
- Released at ≥ 98.0% area-percent by HPLC
Where it is used
Research applications
NAD+ salvage
Inhibiting NNMT spares nicotinamide for salvage to NAD+, making the compound a tool for raising cellular NAD+ without exogenous precursor loading.
Adipocyte metabolism
NNMT is highly expressed in adipose tissue, and inhibition is studied for its effects on adipocyte energy expenditure and differentiation.
One-carbon metabolism
Because NNMT consumes SAM, inhibition changes methyl donor availability, connecting the compound to broader methylation research.
Handling
Reconstitution and stability
Reconstitution
Reconstitute with sterile or bacteriostatic water added slowly against the inner wall of the vial. Allow the cake to dissolve without agitation, swirling gently if required. Do not vortex or shake.
Stability
Lyophilised at −20 °C, desiccated and protected from light, stable for at least 24 months. Reconstituted and held at 2–8 °C, use within 28 days. Avoid repeated freeze-thaw.
Notes
- Bring the vial to room temperature before opening so atmospheric moisture does not condense onto cold powder.
- Record the reconstitution date on the vial; concentration drift between runs is usually evaporation, not synthesis variance.
- Aliquot at first reconstitution where the working programme needs more than a few withdrawals.
Laboratory reference
Reconstitution calculator
Enter the fill weight on the vial and the diluent volume you intend to add. The calculator returns the resulting solution concentration and the volume that contains a given mass.
- Concentration
- 25.000 mg/mL · 25000 µg/mL
- Volume containing target mass
- 10.0 µL · 0.0100 mL
Figures are mass-to-volume arithmetic for laboratory preparation of 5-Amino-1MQ and take no account of net peptide content, which is stated on the batch certificate and should be applied to the fill weight before calculating. Nothing here constitutes dosing, administration or clinical guidance of any kind.
Published work
What the literature reports
Summaries of published findings, provided as research reference. These describe work done by others in preclinical and clinical settings; they are not claims about this material or outcomes for any reader.
NNMT as a metabolic regulator
Work establishing NNMT knockdown as protective against diet-induced obesity in mice, which motivated the search for small-molecule inhibitors.
Kraus et al., Nature, 2014
Small-molecule inhibition
Characterisation of quinolinium-class NNMT inhibitors including effects on adipocyte and muscle preparations.
Neelakantan et al., Biochemical Pharmacology, 2018
Questions
5-Amino-1MQ — asked and answered
Something not covered here? Ask us directly — technical questions reach someone who runs the assays.
- Why is there no CAS number listed?
- Public registry assignment for this salt is inconsistent across sources, and we would rather leave the field blank than publish a number we cannot stand behind. The batch certificate carries the full analytical identity.
- Is this a peptide?
- No. It is a small-molecule quaternary ammonium compound. It appears in this catalogue because the research use sits alongside the metabolic peptides.
- Which solvent should be used?
- Water for aqueous assays, DMSO where higher stock concentrations are needed. Confirm final DMSO tolerance in your cell system.
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Important
5-Amino-1MQ is supplied strictly for laboratory research and analytical use. It is not a medicine, food, cosmetic or veterinary product; it is not for human or animal consumption; and it is not intended to diagnose, treat, cure or prevent any condition. It is not manufactured, tested or released to any standard that would support administration to humans or animals. Information on this page is compiled for research reference and is not medical advice. No dosing, administration or therapeutic guidance is given or implied. By ordering you confirm you are a qualified researcher or institution and accept responsibility for safe handling and lawful use.