137525-51-0
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Fifteen-residue gastric pentadecapeptide fragment studied in angiogenesis and repair models.
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Tissue Repair & Regenerative
KPV
Lys-Pro-Val · α-MSH(11-13)
The C-terminal tripeptide of α-MSH, studied for anti-inflammatory activity without pigmentation effects.
Total, ex VAT
£28.00
- Released at ≥ 98.0% (RP-HPLC, area %)
- Identity confirmed by ESI-MS against theoretical mass
- Batch certificate matched to the vial, verifiable online
- Same working day dispatch before 14:00, tracked
For laboratory research use only. Not for human or veterinary use, and not a medicine, food or cosmetic. Sold to qualified researchers and institutions who accept responsibility for safe handling and lawful use.
Compound data
What is in the vial
Indicative values for this line. The certificate issued with your batch is the authoritative record and reports the measured figures for the material you receive.
- CAS number
- 67247-12-5
- Molecular formula
- C16H30N4O4
- Average mass
- 342.44 g/mol
- Sequence
- Lys-Pro-Val
- Residues
- 3
- Class
- α-MSH C-terminal tripeptide
- Form as supplied
- Lyophilised powder
- Appearance
- White to off-white lyophilised powder
- Purity specification
- ≥ 98.0% (RP-HPLC, area %)
- Solubility
- Soluble in sterile or bacteriostatic water.
- Storage
- Lyophilised: −20 °C, desiccated and dark. Reconstituted: 2–8 °C.
Targets and pathways
- NF-κB signalling
- Melanocortin-independent anti-inflammatory pathways
Overview
About KPV
KPV is the last three residues of α-melanocyte-stimulating hormone. The parent hormone has both anti-inflammatory and pigmentation activity; the tripeptide retains the former without the latter, which is the entire reason it is studied separately.
Its proposed mechanism is interference with NF-κB signalling rather than melanocortin receptor agonism, and the fragment is small enough that receptor-mediated action is unlikely. That makes it a useful counterpart to full-length melanocortin ligands when separating receptor-dependent from receptor-independent effects.
In short
- Three residues — the C-terminal fragment of α-MSH
- Anti-inflammatory activity without pigmentation effects
- Proposed to act on NF-κB rather than through melanocortin receptors
- Released at ≥ 98.0% area-percent by RP-HPLC
Where it is used
Research applications
NF-κB signalling
The principal proposed mechanism, studied in inflammatory cell preparations.
Fragment structure–activity
Demonstrates that a hormone's activities can be separated by fragmentation, a recurring theme across this catalogue.
Mucosal inflammation
A specific literature in intestinal epithelial models, where the fragment has been studied for barrier effects.
Handling
Reconstitution and stability
Reconstitution
Reconstitute with sterile or bacteriostatic water added slowly against the inner wall of the vial. Allow the cake to dissolve without agitation, swirling gently if required. Do not vortex or shake.
Stability
Lyophilised at −20 °C, desiccated and protected from light, stable for at least 24 months. Reconstituted and held at 2–8 °C, use within 28 days. Avoid repeated freeze-thaw.
Notes
- Bring the vial to room temperature before opening so atmospheric moisture does not condense onto cold powder.
- Record the reconstitution date on the vial; concentration drift between runs is usually evaporation, not synthesis variance.
- Aliquot at first reconstitution where the working programme needs more than a few withdrawals.
Laboratory reference
Reconstitution calculator
Enter the fill weight on the vial and the diluent volume you intend to add. The calculator returns the resulting solution concentration and the volume that contains a given mass.
- Concentration
- 5.000 mg/mL · 5000 µg/mL
- Volume containing target mass
- 50.0 µL · 0.0500 mL
Figures are mass-to-volume arithmetic for laboratory preparation of KPV and take no account of net peptide content, which is stated on the batch certificate and should be applied to the fill weight before calculating. Nothing here constitutes dosing, administration or clinical guidance of any kind.
Published work
What the literature reports
Summaries of published findings, provided as research reference. These describe work done by others in preclinical and clinical settings; they are not claims about this material or outcomes for any reader.
Anti-inflammatory fragment activity
Work establishing that the C-terminal tripeptide of α-MSH retains anti-inflammatory activity.
Hiltz & Lipton, FASEB Journal, 1989
Intestinal epithelial studies
Reported effects on inflammatory signalling in intestinal epithelial preparations.
Dalmasso et al., Gastroenterology, 2008
Questions
KPV — asked and answered
Something not covered here? Ask us directly — technical questions reach someone who runs the assays.
- Does it cause pigmentation?
- No. Pigmentation activity resides in the central portion of α-MSH, not the C-terminal tripeptide. That separation is why the fragment is studied.
- Is it a melanocortin receptor agonist?
- It is not generally considered one. At three residues it lacks the pharmacophore for receptor activation, and the proposed mechanism is intracellular.
- How stable is it?
- Very. Three residues, no oxidisable side chains, and a proline in the middle. Standard storage conditions apply.
Same class
Others in Tissue Repair & Regenerative
Important
KPV is supplied strictly for laboratory research and analytical use. It is not a medicine, food, cosmetic or veterinary product; it is not for human or animal consumption; and it is not intended to diagnose, treat, cure or prevent any condition. It is not manufactured, tested or released to any standard that would support administration to humans or animals. Information on this page is compiled for research reference and is not medical advice. No dosing, administration or therapeutic guidance is given or implied. By ordering you confirm you are a qualified researcher or institution and accept responsibility for safe handling and lawful use.