154947-66-7
LL-37
37-residue cationic host defence peptide, the sole human cathelicidin.
Typical release98.5%
From
£98.00
In stock
Immune & Signalling
Thymosin Alpha-1
Tα1 · Thymalfasin
28-residue N-acetylated thymic peptide studied in T-cell maturation and innate signalling.
Total, ex VAT
£72.00
- Released at ≥ 98.0% (RP-HPLC, area %)
- Identity confirmed by ESI-MS against theoretical mass
- Batch certificate matched to the vial, verifiable online
- Same working day dispatch before 14:00, tracked
For laboratory research use only. Not for human or veterinary use, and not a medicine, food or cosmetic. Sold to qualified researchers and institutions who accept responsibility for safe handling and lawful use.
Compound data
What is in the vial
Indicative values for this line. The certificate issued with your batch is the authoritative record and reports the measured figures for the material you receive.
- CAS number
- 62304-98-7
- Molecular formula
- C129H215N33O55
- Average mass
- 3108.3 g/mol
- Residues
- 28
- Class
- N-acetylated thymic peptide
- Form as supplied
- Lyophilised powder
- Appearance
- White to off-white lyophilised powder
- Purity specification
- ≥ 98.0% (RP-HPLC, area %)
- Solubility
- Soluble in sterile or bacteriostatic water.
- Storage
- Lyophilised: −20 °C, desiccated and dark. Reconstituted: 2–8 °C.
Targets and pathways
- Toll-like receptor signalling, principally TLR2 and TLR9
- T-cell maturation and differentiation
Overview
About Thymosin Alpha-1
Thymosin alpha-1 is a 28-residue peptide originally isolated from thymic tissue, N-terminally acetylated in its native form — a modification we reproduce, since the free-amine version is a different compound with different activity.
It is studied principally in T-cell maturation and in innate immune signalling through Toll-like receptors. Its length and its acetylation make identity confirmation important: the des-acetyl form is a common synthesis-related impurity and is reported separately on our certificates where detected.
In short
- 28 residues with native N-terminal acetylation reproduced
- Des-acetyl form reported separately where detected
- Studied in T-cell maturation and TLR-mediated innate signalling
- Released at ≥ 98.0% area-percent by RP-HPLC
Where it is used
Research applications
T-cell maturation
The founding research application, examining thymic peptide contributions to lymphocyte differentiation.
Toll-like receptor signalling
More recent work implicates TLR2 and TLR9 pathways, connecting the peptide to innate as well as adaptive immunity.
Immunomodulation models
Used across a range of preparations where a defined immunomodulatory input is wanted.
Handling
Reconstitution and stability
Reconstitution
Reconstitute with sterile or bacteriostatic water added slowly against the inner wall of the vial. Allow the cake to dissolve without agitation, swirling gently if required. Do not vortex or shake.
Stability
Lyophilised at −20 °C, desiccated and protected from light, stable for at least 24 months. Reconstituted and held at 2–8 °C, use within 28 days. Avoid repeated freeze-thaw.
Notes
- Bring the vial to room temperature before opening so atmospheric moisture does not condense onto cold powder.
- Record the reconstitution date on the vial; concentration drift between runs is usually evaporation, not synthesis variance.
- Aliquot at first reconstitution where the working programme needs more than a few withdrawals.
Laboratory reference
Reconstitution calculator
Enter the fill weight on the vial and the diluent volume you intend to add. The calculator returns the resulting solution concentration and the volume that contains a given mass.
- Concentration
- 2.500 mg/mL · 2500 µg/mL
- Volume containing target mass
- 100.0 µL · 0.1000 mL
Figures are mass-to-volume arithmetic for laboratory preparation of Thymosin Alpha-1 and take no account of net peptide content, which is stated on the batch certificate and should be applied to the fill weight before calculating. Nothing here constitutes dosing, administration or clinical guidance of any kind.
Published work
What the literature reports
Summaries of published findings, provided as research reference. These describe work done by others in preclinical and clinical settings; they are not claims about this material or outcomes for any reader.
Isolation and characterisation
Original isolation from thymosin fraction 5 and determination of the sequence and acetylation.
Goldstein et al., PNAS, 1977
Innate immune signalling
Work identifying Toll-like receptor involvement in the peptide's immunomodulatory effects.
Romani et al., Blood, 2004
Questions
Thymosin Alpha-1 — asked and answered
Something not covered here? Ask us directly — technical questions reach someone who runs the assays.
- Is the N-terminus acetylated?
- Yes. Native thymosin alpha-1 is N-acetylated and we reproduce that. The des-acetyl form is a different compound and is reported separately if present.
- Is thymalfasin the same peptide?
- Yes. Thymalfasin is the international nonproprietary name for thymosin alpha-1.
- How should it be stored?
- −20 °C lyophilised, desiccated and dark. 28 days in solution at 2–8 °C.
Same class
Others in Immune & Signalling
Important
Thymosin Alpha-1 is supplied strictly for laboratory research and analytical use. It is not a medicine, food, cosmetic or veterinary product; it is not for human or animal consumption; and it is not intended to diagnose, treat, cure or prevent any condition. It is not manufactured, tested or released to any standard that would support administration to humans or animals. Information on this page is compiled for research reference and is not medical advice. No dosing, administration or therapeutic guidance is given or implied. By ordering you confirm you are a qualified researcher or institution and accept responsibility for safe handling and lawful use.